2018/12/01
5-Fluorotroxacitabine displays potent anti-leukemic effects and circumvents resistance to Ara-C
Poster presented at the ASH annual meeting in San Diego, USA.
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Poster presented at the ASH annual meeting in San Diego, USA.
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2018/11/14
Suppression of Regulatory T cells (Tregs) in vivo by Small Molecule Targeting of the Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1 (MALT1)
Poster presented at the 30th EORTC-NCI-AACR symposium in Dublin, Ireland
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2018/11/14
Characterization of small molecule inhibitors of ubiquitin specific peptidase 1 (USP1) as anti-cancer agents
Poster presented at the 30th EORTC-NCI-AACR symposium in Dublin, Ireland.
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2018/10/15
The Potential Clinical Relevance of Imaging Biomarker Data from Short Term Interventional Trials in Osteoarthritis
2018/09/25
Identification and characterization of novel small molecule inhibitors of ubiquitin specific peptidase 1 (USP1)
Poster presented at the 16th Annual Discovery on Target i Boston, USA
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2018/08/27
Selective Suppression of Regulatory T-cell Development with Small Molecule Inhibitors of Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1 (MALT1)
Poster presented at the Immuno-Oncology SUMMIT (#IOSummit) in Boston, USA.
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2018/06/04
A phase 1/2 study with birinapant in combination pembrolizumab
Poster presented at the ASCO annual meeting in Chicago, USA.
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2018/05/19
Anti-pruritic properties of Remetinostat (SHAPE), a topical HDAC inhibitor
Presented at the International Investigative Dermatology meeting (IID) in Orlando, USA.
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2018/04/17
Synergistic and additive anti-tumor effects of MIV-818 in combination with sorafenib in nonclinical hepatocellular carcinoma models
Presented at the annual meeting for the American Association for Cancer Research (AACR) in Chicago.
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2018/03/19
The selective cathepsin K inhibitor MIV‑711 attenuates joint pathology in experimental animal models of osteoarthritis
Article published in Journal of Translational Medicine 2018.
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2018/03/02
The biomarker potential of Ki67 and pH2AX immunohistochemistry in guiding use of the liver-targeting nucleotide MIV-818 in patients with hepatocellular carcinoma
2018/03/02
Liver targeting and anti-tumourefficacy of the nucleotide prodrug MIV-818 in nonclinical models of hepatocellular carcinoma
2017/11/08
MIV-711, a novel cathepsin K inhibitor demonstrates evidence of osteoarthritis structure modification
Presented at the Annual Meeting of the American College for Rheumatology in San Diego, USA.
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2017/09/27
Evaluation and characterization of small molecule inhibitors of deubiquitinating enzyme USP14 as potential anti-cancer agents
Presented at the Discovery on Target meeting in Boston, USA
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2017/05/25
Discovery of b-D-20-deoxy-20-dichlorouridine nucleotide prodrugs as potent inhibitors of hepatitis C virus replication
Paper published in Bioorganic & Medicinal Chemistry Letters
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2017/04/28
Liver-targeting with the novel nucleotide prodrug MIV-818 designed for the treatment of liver cancers
Presented at the EASL International Liver Congress in Amsterdam, Netherlands.
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2017/04/19
MIV-802, a uridine nucleotide prodrug, is a more potent inhibitor of HCV genotype 3 replication than sofosbuvir
Presented at EASL, International Liver Congress in Amsterdam, Netherlands.
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2017/04/05
Defining exposure-PD and efficacy relationships with the novel liver-targeting nucleotide prodrug MIV-818 for the treatment of liver cancers
Presented at the American Association for Cancer Research Annual Meeting in Washington, D.C., USA.
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2017/02/15
Selective targeting of the liver with nucleotide prodrugs for the treatment of liver cancers
Presented at the 26th conference of Asian Pacific Association for the study of the liver in Shanghai, China.
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2016/10/03
Discovery of potent small molecule inhibitors of RSV Fusion protein
Presented at the 10th International Respiratory Syncytial Virus Symposium in Argentina.
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Presented at the Discovery on Target meeting in Boston, USA
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2016/09/10
Selective targeting of the liver with nucleotide prodrugs for the treatment of liver cancers
Presented at the International Liver Cancer Association 10th Annual Conference in Canada.
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2016/06/10
Phosphoramidate prodrugs of uridine analogs, including sofosbuvir, are metabolized to both uridine and cytidine triphosphates in Huh7 cells and primary human hepatocytes
Presented at the International Workshop on Clinical Pharmacology of HIV & Hepatitis Therapy in Washington DC, USA.
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2016/04/20
The Cathepsin K inhibitor L-006235 demonstrates both disease modification and attenuation of pain behavior in the MIA model of osteoarthritis
Presented at the OARSI 2016 World Congress in Amsterdam, Netherlands.
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2015/04/22
Preclinical characterisation of MIV-802, a novel uridine nucleotide HCV NS5b polymerase inhibitor, for treatment of hepatitis C virus infection